Gene Detail


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Gene Symbol SVIL
Synonyms MFM10
Gene Description SVIL, supervillin, is a membrane associated actin-binding protein that plays a role in cytoskeletal organization (PMID: 19109420) and cytokinesis (PMID: 24088567), cell migration and motility (PMID: 20331534), and muscle contractility (PMID: 15383618). Elevated SVIL expression has been identified in hepatocellular carcinoma (PMID: 29954442, PMID: 32468064), and a fusion with MAP3K8 has been identified in Spitzoid neoplasms (PMID: 30640733).
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