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Gene Symbol TARBP2
Synonyms LOQS | TRBP | TRBP1 | TRBP2
Gene Description TARBP2, TARBP2 subunit of RISC loading complex, functions as part of the RNA induced silencing complex (RISC) to regulate siRNA mediated gene silencing, acts as an inhibitor of PKR (PMID: 25437560), and regulates RNA stability in the nucleus (PMID: 31300274). Mutations in TARBP2 have been detected in gastrointestinal cancers and Tarbp2 overexpression has been detected in breast cancer (PMID: 22719182, PMID: 24563327, PMID: 30759864) and associated with decreased survival (PMID: 27980417).
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