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Gene Symbol TCF7L2
Synonyms TCF-4 | TCF4
Gene Description TCF7L2, transcription factor 7 like 2, is a HMG box-containing transcription factor which regulates the Wnt signaling pathway and modulates MYC expression (PMID: 18177486, PMID: 9727977). Mutations in Tcf7l2 have been found in colorectal cancers (PMID: 10919662) and premalignant colorectal neoplasia (PMID: 31781186).
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