Gene Detail


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Gene Symbol TLE4
Synonyms BCE-1 | BCE1 | E(spI) | E(spl) | ESG | ESG4 | Grg-4 | GRG4
Gene Description TLE4, transducin-like enhancer protein 4, is a co-repressor that belongs to the Groucho (Gro)/TLE protein family (PMID: 26701208) and may play a role in hematopoiesis and bone development (PMID: 25153823). Overexpression of Tle4 has been observed in colorectal cancer (PMID: 26701208), while decreased expression has been reported in acute myeloid leukemia (PMID: 18258796, PMID: 27636548), and a fusion, TLE4-NTRK2, is associated with ganglioglioma (PMID: 29502353).
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