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Gene Symbol TMPRSS2
Synonyms PRSS10
Gene Description TMPRSS2, transmembrane protease,serine 2, is a member of the type II transmembrane serine protease that is regulated by androgen (PMID: 26018085) and plays a role in viral spread, including coronaviruses (PMID: 30626688). TMPRSS2 fusions frequently occur with ETS transcription factors, including ERG and ETV1, and are commonly observed in prostate cancer (PMID: 20478527, PMID: 30680235, PMID: 31900904, PMID: 31915468).
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