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|Synonyms||DIF | TNF-alpha | TNFA | TNFSF2 | TNLG1F|
|Gene Description||TNF, tumor necrosis factor, is a cytokine member of the TNF superfamily (PMID: 29484738) and is mainly produced by macrophages in response to inflammation (PMID: 30585274). Due to the potent anti-tumor effects of Tnf, its role in immunotherapy is under rapid investigation, but has been hampered, to date, due to high toxicity associated with administration of systemic Tnf (PMID: 30170620, PMID: 29484738).|