Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol TNF
Synonyms DIF | TNF-alpha | TNFA | TNFSF2 | TNLG1F
Gene Description TNF, tumor necrosis factor, is a cytokine member of the TNF superfamily (PMID: 29484738) and is mainly produced by macrophages in response to inflammation (PMID: 30585274). Due to the potent anti-tumor effects of Tnf, its role in immunotherapy is under rapid investigation, but has been hampered, to date, due to high toxicity associated with administration of systemic Tnf (PMID: 30170620, PMID: 29484738).


Additional content available in CKB BOOST