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Gene Symbol TNFAIP3
Synonyms A20 | AISBL | OTUD7C | TNFA1P2
Gene Description TNFAIP3, TNF alpha induced protein 3, encodes an anti-inflammatory protein, acting as a ubiquitin-modifying enzyme, which plays a role in the regulation of multiple signaling pathways including NF-kappaB, Wnt, and interferon regulatory factor (IRF) (PMID: 24246475). Loss of function mutations in TNFAIP3 have been identified in multiple types of lymphomas (PMID: 23134590).


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