Gene Detail


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Gene Symbol TNS1
Synonyms MST091 | MST122 | MST127 | MSTP091 | MSTP122 | MSTP127 | MXRA6 | PPP1R155 | TNS
Gene Description TNS1, tensin 1, encodes for a focal adhesion molecule that links the actin cytoskeleton to integrins, and comprises a SH2 domain rendering it capable of binding phosphotyrosines such as PI3 kinase and FAK (PMID: 28486112). A FGFR2-TNS1 fusion has been identified in triple-receptor negative breast cancer (PMID: 29203461) and a TNS1-ALK fusion has been reported in a uterine mesenchymal tumor (PMID: 31264439).
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