Gene Detail

Gene Symbol TNS1
Synonyms MST091 | MST122 | MST127 | MSTP091 | MSTP122 | MSTP127 | MXRA6 | PPP1R155 | TNS
Gene Description TNS1, tensin 1, encodes for a focal adhesion molecule that links the actin cytoskeleton to integrins, and comprises a SH2 domain rendering it capable of binding phosphotyrosines such as PI3 kinase and FAK (PMID: 28486112). The FGFR2-TNS1 fusion has been identified in triple-receptor negative breast cancer (PMID: 29203461).
Entrez Id 7145
Chromosome 2
Map Location 2q35
Canonical Transcript NM_022648

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