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|Gene Description||TOP1, DNA topoisomerase I, is an enzyme that unwinds DNA during transcription and replication (PMID: 26287259) by forming a stable protein-DNA cleavage complex (TOP1cc) (PMID: 32075966, PMID: 31602296). Amplification of TOP1 has been identified in cancers of the breast, bile duct and pancreas (PMID: 25855483, PMID: 25615400), and a TOP1 autoantibody has been reported in colorectal cancer patients with a more favorable prognosis (PMID: 31922440).|