Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Gene Description||TOP1, DNA topoisomerase I, is an enzyme that unwinds DNA during transcription and replication (PMID: 26287259) by forming a stable protein-DNA cleavage complex (TOP1cc) (PMID: 32075966, PMID: 31602296). Amplification of TOP1 has been identified in cancers of the breast, bile duct and pancreas (PMID: 25855483, PMID: 25615400), and a TOP1 autoantibody has been reported in colorectal cancer patients with a more favorable prognosis (PMID: 31922440).|