Gene Detail

Gene Symbol TOP1
Synonyms TOPI
Gene Description TOP1, topoisomerase (DNA) I, is an enzyme that unwinds DNA during transcription and replication (PMID: 26287259). TOP1 gene copy number gain is commenly identified in cancers of the breast, bile duct and pancreas (PMID: 25855483, PMID: 25615400).
Entrez Id 7150
Chromosome 20
Map Location 20q12
Canonical Transcript NM_003286


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