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Gene Symbol TP53
Synonyms BCC7 | BMFS5 | LFS1 | P53 | TRP53
Gene Description TP53, tumor protein p53, is a tumor suppressor (PMID: 30562755) and oncogene (PMID: 30577483) involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer (PMID: 10065147, PMID: 22713868). TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: 30239254) and somatic missense mutations are frequent in almost all cancer types (PMID: 30224644) and are also implicated in chemoresistance (PMID: 9927204, PMID: 24065105, PMID: 27066457).
ACMG Incidental List v3.0:
Yes, Li-Fraumeni syndrome (PMID: 34012068)

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Molecular Profile Protein Effect Treatment Approaches
TP53 A119P unknown
TP53 A119Qfs*5 loss of function - predicted
TP53 A129Tfs*12 loss of function - predicted p53 Gene Therapy
TP53 A138P loss of function p53 Activator p53 Gene Therapy
TP53 A138T loss of function - predicted p53 Activator p53 Gene Therapy
TP53 A138V loss of function p53 Activator p53 Gene Therapy
TP53 A159fs loss of function - predicted p53 Gene Therapy
TP53 A159G unknown
TP53 A159P unknown
TP53 A159V loss of function p53 Activator p53 Gene Therapy
TP53 A161G unknown
TP53 A161P unknown
TP53 A161T gain of function - predicted
TP53 A161V unknown
TP53 A189D unknown
TP53 A189T unknown
TP53 A189V no effect - predicted
TP53 A276V unknown
TP53 A276_G279del unknown
TP53 A307fs loss of function - predicted p53 Gene Therapy
TP53 A307P unknown
TP53 A307S unknown
TP53 A307T unknown
TP53 A347D loss of function p53 Activator p53 Gene Therapy
TP53 A347P unknown
TP53 A347T loss of function
TP53 A353V unknown
TP53 A74T unknown
TP53 A83V no effect - predicted
TP53 A88fs loss of function - predicted p53 Gene Therapy
TP53 act mut gain of function
TP53 amp no effect
TP53 C124* loss of function - predicted p53 Gene Therapy
TP53 C124fs loss of function - predicted p53 Gene Therapy
TP53 C124G unknown
TP53 C124S gain of function - predicted
TP53 C135Afs*35 loss of function - predicted p53 Gene Therapy
TP53 C135F loss of function - predicted p53 Activator p53 Gene Therapy
TP53 C135fs loss of function - predicted p53 Gene Therapy
TP53 C135S loss of function p53 Activator p53 Gene Therapy
TP53 C135W unknown
TP53 C135Y loss of function
TP53 C141Afs*5 loss of function - predicted p53 Gene Therapy
TP53 C141G unknown
TP53 C141R unknown
TP53 C141S loss of function - predicted
TP53 C141W unknown
TP53 C141Y loss of function p53 Activator p53 Gene Therapy
TP53 C176* loss of function - predicted p53 Gene Therapy
TP53 C176Afs*71 loss of function - predicted p53 Gene Therapy
TP53 C176F loss of function - predicted p53 Activator p53 Gene Therapy
ALK wild-type TP53 C176F
TP53 C176R unknown
BRAF V600E TP53 C176R
TP53 C176S loss of function - predicted
TP53 C176W unknown
TP53 C176Y loss of function
TP53 C182S no effect - predicted
TP53 C229R unknown
TP53 C238F loss of function - predicted
TP53 C238S loss of function p53 Activator p53 Gene Therapy
TP53 C238W unknown
TP53 C238Y unknown
TP53 C238_M246del unknown
TP53 C242Afs*5 loss of function - predicted p53 Gene Therapy
TP53 C242F loss of function
TP53 C242fs loss of function - predicted p53 Gene Therapy
TP53 C242R unknown
TP53 C242S loss of function p53 Activator p53 Gene Therapy
TP53 C242Y loss of function - predicted p53 Activator p53 Gene Therapy
TP53 C242_R248delinsW unknown
TP53 C275* loss of function p53 Gene Therapy
TP53 C275F unknown
TP53 C275S loss of function
TP53 C275Wfs*70 loss of function - predicted p53 Gene Therapy
TP53 C275Y loss of function - predicted
TP53 C277F loss of function p53 Activator p53 Gene Therapy
TP53 C277S gain of function - predicted
TP53 C277Y gain of function - predicted
TP53 D184N no effect
TP53 D21fs loss of function - predicted p53 Gene Therapy
TP53 D228fs loss of function - predicted p53 Gene Therapy
TP53 D228N unknown
TP53 D259G unknown
TP53 D259N unknown
TP53 D259V unknown
TP53 D259Y unknown
TP53 D281A loss of function - predicted
TP53 D281E loss of function - predicted p53 Activator p53 Gene Therapy
TP53 D281G gain of function
TP53 D281H loss of function
TP53 D281N unknown
TP53 D281Y unknown
TP53 D324A unknown
TP53 D324Afs*32 loss of function - predicted p53 Gene Therapy
TP53 D324H unknown
TP53 D324N unknown
TP53 D324Y unknown
TP53 D49H no effect - predicted
TP53 D7A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 dec exp no effect
TP53 del loss of function
TP53 E11Q no effect - predicted
TP53 E171Q unknown
TP53 E171V unknown
TP53 E171_V172insDDV unknown
TP53 E180* loss of function - predicted p53 Gene Therapy
TP53 E180K loss of function p53 Activator p53 Gene Therapy
TP53 E180R loss of function
TP53 E198* loss of function - predicted p53 Gene Therapy
TP53 E198D unknown
TP53 E198_G199del loss of function p53 Activator p53 Gene Therapy
TP53 E204fs loss of function - predicted p53 Gene Therapy
TP53 E204G unknown
TP53 E224* loss of function - predicted p53 Gene Therapy
TP53 E224D unknown
TP53 E224fs loss of function - predicted p53 Gene Therapy
TP53 E224K unknown
TP53 E258* loss of function - predicted p53 Gene Therapy
TP53 E258A unknown
TP53 E258D loss of function p53 Activator p53 Gene Therapy
TP53 E258K loss of function - predicted
TP53 E258Q loss of function
TP53 E271K unknown
TP53 E285* loss of function - predicted
TP53 E285K loss of function
TP53 E285V loss of function p53 Activator p53 Gene Therapy
TP53 E286D unknown
TP53 E286G unknown
TP53 E286K loss of function - predicted p53 Activator p53 Gene Therapy
TP53 E286Q loss of function
TP53 E287A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 E294* loss of function - predicted p53 Activator p53 Gene Therapy
TP53 E294G unknown
TP53 E298* loss of function - predicted p53 Gene Therapy
TP53 E298V unknown
TP53 E326* loss of function - predicted p53 Gene Therapy
TP53 E336* loss of function p53 Gene Therapy
TP53 E339* loss of function - predicted
TP53 E339K no effect
TP53 E343A loss of function - predicted
TP53 E343Gfs*2 unknown
TP53 E346* unknown
TP53 E349* loss of function p53 Gene Therapy
TP53 E349fs unknown
TP53 E358G unknown
TP53 E358V no effect - predicted
TP53 E56* loss of function - predicted
TP53 exon10 unknown
TP53 exon11 unknown
TP53 exon2 unknown
TP53 exon4 unknown
TP53 exon5 unknown
TP53 exon6 unknown
TP53 exon7 unknown
TP53 exon8 unknown
TP53 exon9 unknown
TP53 F109L unknown
TP53 F109Sfs*14 loss of function - predicted p53 Gene Therapy
TP53 F109V unknown
TP53 F113Y unknown
TP53 F134fs loss of function - predicted
TP53 F134L loss of function p53 Activator p53 Gene Therapy
TP53 F134Y loss of function
TP53 F212C unknown
TP53 F212fs loss of function - predicted p53 Gene Therapy
TP53 F212V unknown
TP53 F212Y gain of function - predicted
TP53 F270C unknown
TP53 F270I unknown
TP53 F270L unknown
TP53 F328S unknown
TP53 F338S unknown
TP53 F338Y unknown
TP53 F341C loss of function - predicted
TP53 F341S unknown
TP53 F341V unknown
TP53 F341Y unknown
TP53 G105A unknown
TP53 G105C unknown
TP53 G105D unknown
TP53 G108V unknown
TP53 G112C unknown
TP53 G112D unknown
TP53 G112S unknown
TP53 G117E unknown
TP53 G154A unknown
TP53 G154C unknown
TP53 G154fs loss of function - predicted p53 Gene Therapy
TP53 G154R unknown
TP53 G154S unknown
TP53 G154V loss of function - predicted
TP53 G199* loss of function - predicted
TP53 G226Afs*21 loss of function - predicted p53 Activator p53 Gene Therapy
TP53 G244C unknown
TP53 G244D loss of function
TP53 G244fs loss of function - predicted p53 Gene Therapy
TP53 G244S loss of function p53 Activator p53 Gene Therapy
TP53 G244V unknown
TP53 G245A loss of function p53 Activator p53 Gene Therapy
TP53 G245C loss of function p53 Activator p53 Gene Therapy
TP53 G245D loss of function p53 Activator p53 Gene Therapy
TP53 G245F unknown
TP53 G245fs loss of function - predicted p53 Gene Therapy
TP53 G245R unknown p53 Activator p53 Gene Therapy
TP53 G245S loss of function p53 Activator p53 Gene Therapy
TP53 G245V loss of function p53 Activator p53 Gene Therapy
TP53 G245_M246insAMC unknown
TP53 G262D unknown
TP53 G262R unknown
TP53 G266* loss of function - predicted
TP53 G266E loss of function
TP53 G266R loss of function - predicted p53 Activator p53 Gene Therapy
TP53 G266V unknown
TP53 G279fs loss of function - predicted
TP53 G279Pfs*69 loss of function - predicted
TP53 G279V unknown
TP53 G279_R282del unknown
TP53 G302Afs*42 loss of function - predicted
TP53 G334R unknown
TP53 G334W unknown
TP53 G360A no effect
TP53 G360V gain of function - predicted
TP53 H168D unknown
TP53 H168N no effect
TP53 H168P loss of function p53 Activator p53 Gene Therapy
TP53 H168Q unknown
TP53 H168R loss of function p53 Activator p53 Gene Therapy
ALK wild-type TP53 H168R
TP53 H178N unknown
TP53 H178R unknown
TP53 H178Tfs*69 loss of function - predicted p53 Gene Therapy
TP53 H179D unknown
TP53 H179L loss of function - predicted p53 Activator p53 Gene Therapy
TP53 H179N loss of function p53 Activator p53 Gene Therapy
TP53 H179P unknown
TP53 H179Q loss of function p53 Activator p53 Gene Therapy
TP53 H179R loss of function
TP53 H179Y loss of function p53 Activator p53 Gene Therapy
TP53 H193L unknown
TP53 H193P loss of function p53 Activator p53 Gene Therapy
TP53 H193Q unknown
TP53 H193R unknown
TP53 H193Y unknown
TP53 H214Qfs*7 loss of function - predicted p53 Gene Therapy
TP53 H214R gain of function - predicted
TP53 H214Y unknown
TP53 H233_Y234del loss of function p53 Activator p53 Gene Therapy
TP53 H296Y unknown
TP53 H297L unknown
TP53 H297P unknown
TP53 H297R unknown
TP53 I162F unknown
TP53 I195* TP53 R248Q
TP53 I195* loss of function - predicted p53 Gene Therapy
TP53 I195F unknown
TP53 I195M unknown
TP53 I195N unknown
TP53 I195S unknown
TP53 I195T loss of function
TP53 I232S loss of function
TP53 I232T loss of function - predicted
TP53 I251M unknown
TP53 I251N unknown
TP53 I251S unknown p53 Activator p53 Gene Therapy
TP53 I254N loss of function - predicted
TP53 I254T loss of function p53 Activator p53 Gene Therapy
TP53 I254V no effect - predicted
TP53 I255del loss of function p53 Activator p53 Gene Therapy
TP53 I255N unknown
TP53 I255S unknown
TP53 I332N unknown
TP53 I332Pfs*14 loss of function p53 Gene Therapy
TP53 I332S unknown
TP53 I332T unknown
TP53 I50S unknown
TP53 inact mut loss of function p53 Activator p53 Gene Therapy
TP53 K101N unknown
TP53 K101Q unknown
TP53 K120* loss of function - predicted
TP53 K120A loss of function
TP53 K120E loss of function
TP53 K132E unknown
TP53 K132M unknown
TP53 K132N loss of function - predicted p53 Gene Therapy
TP53 K132Q unknown
TP53 K132R unknown
TP53 K132T unknown
TP53 K139fs loss of function - predicted p53 Gene Therapy
TP53 K139M unknown
TP53 K139R no effect - predicted
TP53 K164E unknown
TP53 K164M unknown
TP53 K164N unknown
TP53 K164Q unknown
TP53 K164T unknown
TP53 K24I unknown
TP53 K24Nfs*20 loss of function - predicted
TP53 K291E gain of function - predicted
TP53 K291Q gain of function - predicted
TP53 K291T gain of function - predicted
TP53 K292I gain of function - predicted
TP53 K292Q unknown
TP53 K292T gain of function - predicted
TP53 K305* loss of function - predicted
TP53 K305M unknown
TP53 K305N unknown
TP53 K305T unknown
TP53 K319E unknown
TP53 K319R unknown
TP53 K320E unknown
TP53 K320Q loss of function
TP53 K320R loss of function
TP53 K320T loss of function - predicted
TP53 K321E unknown
TP53 K321R unknown
TP53 K351E loss of function - predicted p53 Activator p53 Gene Therapy
TP53 K351N loss of function
TP53 K351Q loss of function - predicted p53 Activator p53 Gene Therapy
TP53 K351R no effect - predicted
TP53 K357Q no effect - predicted
TP53 K357R loss of function - predicted p53 Activator p53 Gene Therapy
TP53 K382Nfs*96 unknown
TP53 L111fs loss of function - predicted p53 Gene Therapy
TP53 L111M unknown
TP53 L111P unknown
TP53 L111Q unknown
TP53 L111Wfs*12 loss of function p53 Activator p53 Gene Therapy
TP53 L114fs loss of function - predicted p53 Gene Therapy
TP53 L130F unknown
TP53 L130I unknown
TP53 L130R unknown
TP53 L130V unknown
TP53 L137M unknown
TP53 L137Q unknown
TP53 L145Q unknown
TP53 L194F loss of function p53 Activator p53 Gene Therapy
TP53 L194R loss of function p53 Activator p53 Gene Therapy
TP53 L206F unknown
TP53 L22P unknown
TP53 L252_I254dup unknown
TP53 L257Gfs*6 loss of function - predicted p53 Gene Therapy
TP53 L257V unknown
TP53 L265P loss of function - predicted
TP53 L265V unknown
TP53 L289D loss of function - predicted
TP53 L299R unknown
TP53 L308R unknown
TP53 L323R unknown
TP53 L323V no effect - predicted
TP53 L330A loss of function
TP53 L330H loss of function
TP53 L330P loss of function
TP53 L330R loss of function
TP53 L344A loss of function
TP53 L344P loss of function
TP53 L344Q loss of function - predicted
TP53 L344R loss of function
TP53 L348A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 L348S loss of function p53 Activator p53 Gene Therapy
TP53 L350P loss of function
TP53 loss loss of function
ALK rearrange RB1 C706F TP53 loss
PTEN loss TP53 loss
TP53 M133K loss of function - predicted
TP53 M160K unknown
TP53 M160R unknown
TP53 M237I loss of function
TP53 M237K unknown
TP53 M237V unknown
TP53 M237_S241del unknown
TP53 M243T unknown
TP53 M246A unknown
TP53 M246I loss of function p53 Activator p53 Gene Therapy
TP53 M246K loss of function
TP53 M246R loss of function - predicted p53 Activator p53 Gene Therapy
TP53 M246T unknown
TP53 M40fs loss of function - predicted p53 Gene Therapy
TP53 M44fs loss of function - predicted p53 Gene Therapy
TP53 mutant unknown
PTEN mut TP53 mut
RB1 mut TP53 mut
RB1 wild-type TP53 mut
ALK wild-type TP53 mut
BRAF mut TP53 mut
ALK rearrange TP53 mut
ROS1 rearrange TP53 mut
ATM wild-type TP53 mut
NRAS mut TP53 mut
TP53 N131D unknown
TP53 N131fs loss of function - predicted p53 Gene Therapy
TP53 N131K unknown
TP53 N131S unknown
TP53 N131T unknown
TP53 N200K unknown
TP53 N210Kfs*37 loss of function
TP53 N235D loss of function p53 Activator p53 Gene Therapy
TP53 N235S no effect - predicted
TP53 N235Y unknown
TP53 N239D unknown
TP53 N239I unknown
TP53 N239S loss of function p53 Activator p53 Gene Therapy
TP53 N239T unknown
TP53 N239_C242del unknown
TP53 N247D unknown
TP53 N263D no effect
TP53 N268I unknown
TP53 N288D unknown
TP53 N30fs loss of function - predicted p53 Gene Therapy
TP53 N310H unknown
TP53 N310I unknown
TP53 N310S unknown
TP53 N311S no effect
TP53 N345* loss of function p53 Gene Therapy
TP53 N345D unknown
TP53 N345Ifs*26 loss of function p53 Gene Therapy
TP53 N345Y unknown
TP53 negative loss of function
TP53 over exp no effect
TP53 P128fs loss of function - predicted p53 Gene Therapy
TP53 P12S unknown
TP53 P142L unknown
TP53 P151H loss of function p53 Activator p53 Gene Therapy
TP53 P151L unknown
TP53 P151R unknown
TP53 P151S loss of function p53 Activator p53 Gene Therapy
TP53 P152fs loss of function - predicted p53 Gene Therapy
TP53 P152L loss of function p53 Activator p53 Gene Therapy
TP53 P177A unknown
TP53 P177L unknown
TP53 P177S unknown
TP53 P177T loss of function
ALK wild-type TP53 P177T
TP53 P177_E180del unknown
TP53 P190A unknown
TP53 P190L unknown
TP53 P190R loss of function - predicted
TP53 P190S loss of function p53 Activator p53 Gene Therapy
TP53 P190T unknown
TP53 P191fs loss of function - predicted p53 Gene Therapy
TP53 P191R unknown
TP53 P219fs loss of function - predicted p53 Activator p53 Gene Therapy
TP53 P219S loss of function p53 Activator p53 Gene Therapy
TP53 P222L no effect - predicted
TP53 P223L unknown
TP53 P223L TP53 V274F
TP53 P223R unknown
TP53 P223T unknown
TP53 P250L loss of function
TP53 P278A loss of function p53 Activator p53 Gene Therapy
TP53 P278F unknown
TP53 P278H unknown
ROS1 rearrange ROS1 L2026M TP53 P278H
TP53 P278L unknown
TP53 P278R loss of function - predicted
TP53 P278S loss of function p53 Activator p53 Gene Therapy
TP53 P278T unknown
TP53 P27Lfs*17 loss of function - predicted p53 Gene Therapy
TP53 P27S unknown
TP53 P295A unknown
TP53 P295L unknown
TP53 P295S no effect - predicted
TP53 P300A unknown
TP53 P300H unknown
TP53 P300R unknown
TP53 P301fs loss of function - predicted p53 Gene Therapy
TP53 P301Q unknown
TP53 P301R unknown
TP53 P309S unknown
TP53 R273H TP53 P309S
TP53 P322A unknown
TP53 P322Q unknown
TP53 P322R unknown
TP53 P322S unknown
TP53 P359L unknown
TP53 P47S unknown
TP53 P58R no effect - predicted
TP53 P72fs loss of function - predicted p53 Gene Therapy
TP53 P72R unknown
TP53 P72R TP53 Y220C
TP53 P77S no effect - predicted
TP53 P82Gfs*66 loss of function - predicted p53 Gene Therapy
TP53 P82Rfs*41 loss of function - predicted p53 Gene Therapy
TP53 P87Ifs*54 loss of function - predicted
TP53 P98A loss of function p53 Activator p53 Gene Therapy
TP53 P98fs loss of function - predicted p53 Gene Therapy
TP53 P98fs TP53 R175C TP53 S215G
TP53 P98L unknown
TP53 P98R unknown
TP53 P98S unknown
TP53 positive unknown
TP53 Q100P unknown
TP53 Q100R unknown
TP53 Q104* loss of function - predicted p53 Gene Therapy
TP53 Q104H unknown
TP53 Q136* loss of function - predicted p53 Gene Therapy
TP53 Q136L unknown
TP53 Q144* loss of function - predicted p53 Gene Therapy
TP53 Q165* loss of function - predicted p53 Gene Therapy
TP53 Q167L unknown
TP53 Q192* loss of function - predicted p53 Gene Therapy
TP53 Q192K unknown
BRAF V600E TP53 Q192K
TP53 Q192L unknown
TP53 Q317* loss of function - predicted p53 Gene Therapy
TP53 Q331* loss of function - predicted p53 Gene Therapy
EML4 - ALK TP53 Q331*
TP53 Q331H unknown
TP53 Q52Lfs*68 loss of function - predicted
TP53 R110C loss of function - predicted
TP53 R110H no effect - predicted
TP53 R110L loss of function p53 Activator p53 Gene Therapy
TP53 R110P loss of function p53 Activator p53 Gene Therapy
TP53 R110Vfs*13 loss of function - predicted p53 Gene Therapy
TP53 R156C no effect - predicted
TP53 R156H unknown
TP53 R156P loss of function p53 Activator p53 Gene Therapy
TP53 R158C unknown
TP53 R158fs loss of function - predicted p53 Gene Therapy
TP53 R158G loss of function - predicted
TP53 R158H loss of function p53 Activator p53 Gene Therapy
TP53 R158L loss of function p53 Activator p53 Gene Therapy
TP53 R158P loss of function
TP53 R174G unknown
TP53 R174M unknown
TP53 R174Q unknown
TP53 R175A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R175C no effect
TP53 R175G loss of function - predicted
TP53 R175H loss of function p53 Activator p53 Gene Therapy
TP53 R175L loss of function p53 Activator p53 Gene Therapy
TP53 R175P unknown
TP53 R175X unknown
TP53 R181C loss of function
TP53 R181E loss of function
TP53 R181G unknown
TP53 R181H loss of function - predicted
TP53 R181L loss of function
TP53 R181P loss of function p53 Activator p53 Gene Therapy
TP53 R181S unknown
TP53 R196* loss of function - predicted p53 Gene Therapy
TP53 R196G loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R196L unknown
TP53 R196P unknown
TP53 R209fs loss of function - predicted p53 Gene Therapy
TP53 R209Kfs*6 loss of function - predicted p53 Gene Therapy
TP53 R213* loss of function - predicted p53 Gene Therapy
ATM T1200Lfs*7 NRAS Q61K TP53 R213*
TP53 R213fs loss of function - predicted p53 Gene Therapy
TP53 R213G unknown
TP53 R213L unknown
TP53 R213Q loss of function - predicted
TP53 R248E unknown p53 Activator p53 Gene Therapy
TP53 R248G loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R248L loss of function p53 Activator p53 Gene Therapy
TP53 R248P loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R248Q loss of function p53 Activator p53 Gene Therapy
TP53 R248W loss of function p53 Activator p53 Gene Therapy
TP53 R248W VHL inact mut
RB1 K240Sfs*22 TP53 R248W
JAK2 V617F TP53 R248W
TP53 R249G loss of function p53 Activator p53 Gene Therapy
TP53 R249Gfs*96 loss of function - predicted
TP53 R249K unknown p53 Activator p53 Gene Therapy
TP53 R249M loss of function p53 Activator p53 Gene Therapy
TP53 R249S loss of function p53 Activator p53 Gene Therapy
TP53 R249T unknown p53 Activator p53 Gene Therapy
TP53 R249W gain of function p53 Activator p53 Gene Therapy
TP53 R267L unknown
TP53 R267P unknown
TP53 R267Q unknown
TP53 R267W loss of function p53 Activator p53 Gene Therapy
TP53 R273* loss of function - predicted p53 Gene Therapy
TP53 R273C loss of function p53 Activator p53 Gene Therapy
TP53 R273H loss of function p53 Activator p53 Gene Therapy
BRAF V600E PIK3CA P449T TP53 R273H
TP53 R273L loss of function p53 Activator p53 Gene Therapy
TP53 R273P loss of function p53 Activator p53 Gene Therapy
TP53 R273S loss of function p53 Activator p53 Gene Therapy
TP53 R273W loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R273X unknown
TP53 R273Y unknown
TP53 R280A loss of function p53 Activator p53 Gene Therapy
TP53 R280D loss of function p53 Activator p53 Gene Therapy
TP53 R280G unknown
TP53 R280I unknown p53 Activator p53 Gene Therapy
TP53 R280K gain of function
TP53 R280M loss of function
TP53 R280T loss of function p53 Activator p53 Gene Therapy
TP53 R282D loss of function p53 Activator p53 Gene Therapy
TP53 R282fs loss of function - predicted p53 Gene Therapy
TP53 R282G loss of function
TP53 R282H unknown
TP53 R282Q gain of function p53 Activator p53 Gene Therapy
TP53 R282W loss of function p53 Activator p53 Gene Therapy
TP53 R283A loss of function - predicted
TP53 R283Afs*62 loss of function - predicted
TP53 R283C loss of function
TP53 R283del loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R283H unknown
TP53 R283P unknown
TP53 R290G gain of function - predicted
TP53 R290H no effect
TP53 R306* loss of function - predicted p53 Gene Therapy
TP53 R333fs loss of function - predicted p53 Gene Therapy
TP53 R333P unknown
TP53 R333Vfs*12 loss of function - predicted p53 Gene Therapy
TP53 R335fs loss of function - predicted p53 Gene Therapy
TP53 R335H unknown p53 Activator p53 Gene Therapy
TP53 R337C loss of function p53 Activator p53 Gene Therapy
TP53 R337H loss of function
TP53 R337L loss of function p53 Activator p53 Gene Therapy
TP53 R337P loss of function p53 Activator p53 Gene Therapy
TP53 R337S unknown
TP53 R342* loss of function p53 Gene Therapy
TP53 R342fs loss of function - predicted p53 Gene Therapy
TP53 R342P loss of function
TP53 R65* loss of function - predicted p53 Gene Therapy
TP53 S106N unknown
TP53 S106T unknown
TP53 S116C unknown
TP53 S121A gain of function - predicted
TP53 S121C gain of function - predicted
TP53 S121F gain of function - predicted
TP53 S127F unknown
TP53 S127Y unknown
TP53 S149fs loss of function - predicted
TP53 S166Cfs*6 loss of function - predicted p53 Gene Therapy
TP53 S166Yfs*4 loss of function - predicted p53 Gene Therapy
TP53 S183* loss of function - predicted
TP53 S183L unknown
TP53 S185R unknown
TP53 S20fs loss of function - predicted p53 Gene Therapy
TP53 S215fs loss of function - predicted p53 Gene Therapy
TP53 S215G loss of function p53 Activator p53 Gene Therapy
TP53 S215I loss of function - predicted p53 Activator p53 Gene Therapy
TP53 S215R unknown
TP53 S215T unknown
TP53 S227F unknown
TP53 S227fs loss of function - predicted p53 Gene Therapy
TP53 S227Lfs*20 loss of function p53 Gene Therapy
TP53 S227P unknown
TP53 S240I unknown p53 Activator p53 Gene Therapy
TP53 S240Kfs*25 loss of function - predicted p53 Gene Therapy
TP53 S240R loss of function
TP53 S240T unknown
TP53 S241C unknown
TP53 S241F loss of function p53 Activator p53 Gene Therapy
TP53 S241fs loss of function - predicted p53 Gene Therapy
TP53 S241Y loss of function p53 Activator p53 Gene Therapy
TP53 S269R unknown
TP53 S303G unknown
TP53 S303R unknown
TP53 S33A unknown
TP53 S362C unknown
TP53 S366A no effect - predicted
TP53 S366Y unknown
TP53 S378P no effect - predicted
TP53 S392fs unknown
TP53 S46fs loss of function - predicted p53 Gene Therapy
TP53 S90fs loss of function - predicted p53 Gene Therapy
PIK3CA H1047R TP53 S90fs
TP53 S94* loss of function - predicted
TP53 S96A unknown
TP53 S96F unknown
TP53 S96P unknown
TP53 S99A unknown
TP53 S99F unknown
TP53 S99P unknown
TP53 S99Y unknown
TP53 S9N unknown
TP53 T102A loss of function - predicted
TP53 T118fs loss of function - predicted p53 Gene Therapy
TP53 T118Qfs*5 loss of function - predicted p53 Gene Therapy
TP53 T125A loss of function
TP53 T140I unknown
TP53 T140S unknown
TP53 T140_C141del unknown
TP53 T150_P151del unknown
TP53 T155fs loss of function - predicted p53 Gene Therapy
TP53 T155P unknown
TP53 T170M unknown
TP53 T170P unknown
TP53 T211A gain of function - predicted
TP53 T211Ffs*4 loss of function - predicted p53 Gene Therapy
TP53 T211I loss of function - predicted
TP53 T211S unknown
TP53 T230P unknown
TP53 T253I unknown
TP53 T256fs loss of function - predicted p53 Gene Therapy
TP53 T256I unknown
TP53 T256K unknown
TP53 T284A no effect
TP53 T312S no effect - predicted
TP53 T329A no effect
TP53 T329fs loss of function - predicted p53 Gene Therapy
TP53 T377P unknown
TP53 T377S unknown
TP53 - NTRK1 unknown Larotrectinib
TP53 V122E unknown
TP53 V122fs loss of function - predicted p53 Gene Therapy
TP53 V122M unknown
TP53 V143A loss of function p53 Activator p53 Gene Therapy
TP53 V147A unknown
TP53 V147L unknown
TP53 V157D loss of function - predicted
TP53 V157F loss of function
TP53 V157fs loss of function - predicted p53 Gene Therapy
TP53 V157L unknown
TP53 V157P unknown
TP53 V172F loss of function - predicted
TP53 V173A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 V173dup unknown
TP53 V173G unknown
TP53 V173L loss of function
TP53 V173M loss of function - predicted p53 Activator p53 Gene Therapy
TP53 V197L loss of function - predicted
TP53 V197M unknown
TP53 V203E unknown
TP53 V203L unknown
TP53 V203M unknown
TP53 V216G unknown
TP53 V216M loss of function - predicted
TP53 V217M no effect
TP53 V218del unknown
TP53 V272A unknown
TP53 V272L unknown
TP53 V272M loss of function p53 Activator p53 Gene Therapy
TP53 V274A unknown
TP53 V274D unknown
TP53 V274F loss of function p53 Activator p53 Gene Therapy
TP53 V274fs loss of function - predicted p53 Gene Therapy
EML4 - ALK TP53 V274fs
TP53 V31I no effect - predicted
TP53 V73M no effect - predicted
TP53 W146* loss of function - predicted p53 Gene Therapy
TP53 W53* loss of function - predicted p53 Gene Therapy
TP53 W91* loss of function - predicted
TP53 W91fs loss of function - predicted p53 Gene Therapy
TP53 W91Gfs*32 loss of function - predicted p53 Gene Therapy
TP53 wild-type no effect
BRAF mut TP53 wild-type
RB1 wild-type TP53 wild-type
ALK R1275Q TP53 wild-type
ALK F1174L TP53 wild-type
ALK F1245C TP53 wild-type
ALK act mut TP53 wild-type
ALK mut TP53 wild-type
ALK amp TP53 wild-type
ALK wild-type TP53 wild-type
BRAF V600E PIK3CA H1047R TP53 wild-type
BRAF V600E PTEN loss TP53 wild-type
TET2 inact mut TP53 wild-type
TET2 loss TP53 wild-type
NRAS mut TP53 wild-type
BTK C481S TP53 wild-type
ALK F1174C TP53 wild-type
ALK F1174V ALK amp TP53 wild-type
TP53 Y103* loss of function - predicted p53 Gene Therapy
TP53 Y103fs loss of function - predicted p53 Gene Therapy
TP53 Y103S unknown
TP53 Y103Sfs*18 loss of function - predicted p53 Gene Therapy
TP53 Y107H unknown
TP53 Y107N unknown
TP53 Y126C loss of function - predicted p53 Activator p53 Gene Therapy
TP53 Y126H loss of function p53 Activator p53 Gene Therapy
TP53 Y126S unknown
TP53 Y163* loss of function - predicted p53 Gene Therapy
TP53 Y163C loss of function p53 Activator p53 Gene Therapy
TP53 Y163H unknown
TP53 Y163N loss of function
TP53 Y205* loss of function - predicted p53 Gene Therapy
TP53 Y205C loss of function p53 Activator p53 Gene Therapy
TP53 Y220C loss of function p53 Activator p53 Gene Therapy
TP53 Y220S unknown
TP53 Y234C loss of function p53 Activator p53 Gene Therapy
TP53 Y234H loss of function p53 Activator p53 Gene Therapy
TP53 Y234N unknown
TP53 Y234S unknown
TP53 Y236C loss of function p53 Activator p53 Gene Therapy
TP53 Y236F unknown
TP53 Y327L unknown p53 Activator p53 Gene Therapy