Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol TRPM2
Synonyms EREG1 | KNP3 | LTrpC-2 | LTRPC2 | NUDT9H | NUDT9L1 | TRPC7
Gene Description TRPM2, transient receptor potential cation channel subfamily M member 2, is a member of the transient receptor potential (TRP) protein super-family that is activated by oxidative stress (PMID: 28008929) to regulate calcium and sodium flux across membranes (PMID: 27068538) and may play a role in neutrophil recruitment (PMID: 30251149) and autophagy (PMID: 29875336, PMID: 29343514). Overexpression of Trpm2 has been observed in oral squamous cell carcinoma (PMID: 28008929) and somatic mutations may be correlated with decreased survival in pancreatic cancer (PMID: 29620272).


Additional content available in CKB BOOST