Gene Detail


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Gene Symbol VAV2
Synonyms VAV-2
Gene Description VAV2, vav guanine nucleotide exchange factor 2, is a member of the Dbl protein family activated by Egf and Pdgf that acts as a guanine nucleotide exchange factor for Rho family GTPases (PMID: 10744696, PMID: 11448999), and is involved in cell migration (PMID: 10982832), lamellipodia formation (PMID: 11448999, PMID: 10982832), and cell spreading (PMID: 11448999). VAV2 overexpression has been identified in gastric cancer (PMID: 28459214).
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