Gene Detail

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Gene Symbol VCL
Synonyms CMD1W | CMH15 | HEL114 | MV | MVCL
Gene Description VCL, vinculin, interacts with F-actin and other cytoskeletal proteins and regulates cell adhesion and migration (PMID: 23466368, PMID: 26195589). VCL-ALK fusions have been identified in pediatric renal cell carcinoma (PMID: 26773439), epithelioid cell histiocytoma (PMID: 25413595), and adult renal cell carcinoma (PMID: 31563285), a VCL-NTRK2 fusion has been identified in pediatric glioma (PMID: 24705251), and Vcl overexpression has been associated with decreased survival in gastric cancer (PMID: 30989694).


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