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Gene Symbol WNT1
Synonyms BMND16 | INT1 | OI15
Gene Description WNT1, Wnt family member 1, is a secreted cytokine that binds the receptors, frizzled (Fz) and low density lipoprotein receptor-related protein (LRP), to activate beta-catenin (CTNNB1; PMID: 27197202, PMID: 28528193) and functions in bone development and cell migration (PMID: 27626678). Overexpression of WNT1 has been observed in a variety of tumors, including renal cell carcinoma, hepatocellular carcinoma, thyroid carcinoma, head and neck squamous cell carcinoma, and uterine corpus endometrial carcinoma (PMID: 32201670), potentially resulting in cell proliferation and metastasis (PMID: 27626678).
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