Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol WNT1
Synonyms BMND16 | INT1 | OI15
Gene Description WNT1, Wnt family member 1, is a secreted cytokine that binds the receptors, frizzled (Fz) and low density lipoprotein receptor-related protein (LRP), to activate beta-catenin (CTNNB1; PMID: 27197202, PMID: 28528193) and functions in bone development and cell migration (PMID: 27626678). Overexpression of WNT1 has been observed in a variety of tumors, including renal cell carcinoma, hepatocellular carcinoma, thyroid carcinoma, head and neck squamous cell carcinoma, and uterine corpus endometrial carcinoma (PMID: 32201670), potentially resulting in cell proliferation and metastasis (PMID: 27626678).


Additional content available in CKB BOOST