Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol WT1
Synonyms AWT1 | GUD | NPHS4 | WAGR | WIT-2 | WT33
Gene Description WT1, WT1 transcription factor, encodes a transcription factor responsible for targeting genes related to cell growth and metabolism (PMID: 17361230), such as VEGF and BCL2 (PMID: 32152317). Germline mutations in WT1 are involved in the development of Wilms' tumor of the kidney and somatic mutations are observed in other cancers, including acute myeloid leukemia (PMID: 16987884, PMID: 17361230, PMID: 32122281), and normal karyotype acute myeloid leukemia, where mutations may predict a poor prognosis (PMID: 32019476).


Additional content available in CKB BOOST