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Gene Symbol YES1
Synonyms c-yes | HsT441 | P61-YES | Yes
Gene Description YES1, YES proto-oncogene 1, Src family tyrosine kinase, is a nonreceptor tyrosine kinase regulating proliferation, migration, and cytoskeletal function (PMID: 21566460) through activation of CDK4, CTNND1, and YAP1 (PMID: 31391186). YES1 amplification and overexpression has been reported in HER2-positive breast cancer (PMID: 28158234) and in esophageal, uterine, bladder, lung, and head and neck cancers (PMID: 31391186).
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