Gene Detail


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Gene Symbol SHOC2
Synonyms NSLH1 | SIAA0862 | SOC2 | SUR8
Gene Description SHOC2, leucine-rich repeat protein SHOC-2, is a scaffold protein that forms a complex with protein phosphatase 1 (PP1c) to activate Raf1 kinase and subsequent ERK1/2 signaling (PMID: 27574535, PMID: 26876614). Preclinical studies have implicated Shoc2 in tumorgenesis through accelerated activation of ERK1/2 kinase (PMID: 27574535).
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