Gene Detail

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Gene Symbol LZTR1
Synonyms BTBD29 | LZTR-1 | NS10 | NS2 | SWNTS2
Gene Description LZTR1, leucine zipper like transcription regulator 1, is a Golgi protein and member of the BTB/POZ superfamily that plays a role in protein degradation of RAS-GTPases (PMID: 31533111) and functions as an adaptor protein for Cullin3 (CUL3)-basedE3 ubiquitin ligase (PMID: 31337872). Germline mutations in LZTR1 have been reported in Noonan syndrome (PMID: 31825158) and schwannomatosis (PMID: 29409008, PMID: 27472264), while Lztr1 expression is downregulated or inactivated in several tumor types (PMID: 24362817, PMID: 23917401, PMID: 18686028).


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