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Gene Symbol ARMC10
Synonyms PNAS-112 | PNAS112 | PSEC0198 | SVH
Gene Description ARMC10, armadillo repeat containting 10, directly decreases the transcriptional activity of Tp53 via binding to the DNA binding domain (PMID: 17904127) and mediates mitochondrial dynamics by serving as a substrate for AMP-activated protein kinase (AMPK) (PMID: 30631047). ARMC10 fusions with BRAF have been observed in lung cancer (PMID: 26314551) and melanoma (PMID: 30254212, PMID: 27864876).
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