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Gene Symbol ZIC4
Gene Description ZIC4, Zic family member 4, encodes a zinc finger transcription factor that negatively regulates sonic hedgehog signaling (PMID: 27553089) and is expressed during embryogenesis, specifically playing a role in cerebellar development (PMID: 15338008, PMID: 21307096). ZIC4 overexpression has been identified in medulloblastoma (PMID: 20199689) and methylation of ZIC4 has been identified in head and neck cancer (PMID: 27553089).
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