Gene Detail

Gene Symbol ZNRF3
Synonyms BK747E2.3 | RNF203
Gene Description ZNRF3, E3 ubiquitin-protein ligase ZNRF3, is a E3 ubiquitin ligase that negatively regulates the Wnt receptor pathway by degrading frizzled and LRP6 (PMID: 22575959). ZNRF3 is a putative tumor suppressor that has been observed to have decreased expression in papillary thyroid carcinoma (PMID: 27448298) and mutations have been reported in colorectal cancer (PMID: 27661107).
Entrez Id 84133
Chromosome 22
Map Location 22q12.1
Canonical Transcript NM_001206998

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