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Gene Symbol NR0B2
Synonyms SHP | SHP1
Gene Description NR0B2, nuclear receptor subfamily 0 group B member 2, encodes for a nuclear receptor that plays a significant role in regulating metabolic pathways and demonstrates functionality related to transcriptional corepression (PMID: 27540300). Loss of NR0B2 has been shown to be associated with development of hepatocellular carcinoma (PMID: 26504773) and hypermethylation of the NR0B2 promoter has been associated with decreased expression in clear cell renal cell carcinoma (PMID: 29989580).
Additional content available in CKB BOOST