Gene Detail

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Gene Symbol RAD54L
Synonyms hHR54 | HR54 | hRAD54 | RAD54A
Gene Description RAD54L, RAD54-like, is a member of the SWI2/SNF2 family of dsDNA-dependent ATPases, which functions in homologous recombination in DNA repair (PMID: 20089461, PMID: 21704205). Overexpression of Rad54l has been demonstrated in non-small cell lung cancer (PMID: 21412013).

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Molecular Profile Protein Effect Treatment Approaches
RAD54L amp no effect
RAD54L del loss of function Olaparib
RAD54L E297* loss of function - predicted Olaparib
RAD54L E436* loss of function - predicted Olaparib
RAD54L F82S loss of function - predicted Olaparib
RAD54L H110A unknown
RAD54L inact mut loss of function Olaparib
RAD54L K189A loss of function Olaparib
RAD54L K189R loss of function Olaparib
RAD54L L109Q unknown
RAD54L L381Cfs*8 loss of function - predicted Olaparib
RAD54L loss loss of function Olaparib
RAD54L mutant unknown
RAD54L over exp no effect
RAD54L P112A unknown
RAD54L P694L unknown
RAD54L P85A loss of function - predicted Olaparib
RAD54L Q90* loss of function - predicted Olaparib
RAD54L R75* loss of function - predicted Olaparib
RAD54L S49E loss of function Olaparib
RAD54L Y309* loss of function - predicted Olaparib