Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||BENTA | BIMP3 | CARMA1 | IMD11 | IMD11A | PPBL|
|Gene Description||CARD11, caspase recruitment domain family, member 11, is a component of a scaffold complex that regulates NFKB activity (PMID: 23149938). Activating mutations in the CARD11 coiled-coil domain activate NFKB and have been identified in hematological cancers, including diffuse large B cell lymphoma and may confer resistance to ibrutinib (PMID: 23149938, PMID: 18323416, PMID: 27224912).|