Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol TRIM63
Synonyms IRF | MURF1 | MURF2 | RNF28 | SMRZ
Gene Description TRIM63, tripartite motif containing 63, is a E3 ubiquitin-protein ligase, specifically expressed in cardiac and skeletal muscles where it functions to degrade thick filament proteins (PMID: 22821932). A fusion of TRIM63 with NTRK1 has been observed in melanoma (PMID: 29683819, PMID: 28719467) and increased Trim63 expression has been observed in breast cancer (PMID: 31399258).


Additional content available in CKB BOOST