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|Synonyms||CRISTIN1 | PWTSR | THSD2|
|Gene Description||RSPO3, R-spondin 3, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO3 fusions with PTPRK (PTPRK-RPSO3) have been frequently identified in colorectal cancer (PMID: 26924569) and decreased RSPO3 expression has been observed with prostate cancer invasiveness (PMID: 30987640), whereas overexpression of RSPO3 has been observed in bladder cancer (PMID: 30329043).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RSPO3 fusion||colorectal cancer||conflicting||GSK3178022||Preclinical - Pdx||Actionable||In a preclinical study, GSK3178022 inhibited Wnt signaling and delayed tumor growth in a patient-derived xenograft (PDX) model of colorectal cancer harboring an RSPO3 translocation, however, failed to inhibit Wnt signaling or tumor growth in a second RSPO3 translocation-positive colorectal cancer PDX model (PMID: 27401612).||27401612|
|RSPO3 over exp||cancer||not applicable||N/A||Preclinical - Pdx & cell culture||Emerging||In a preclinical study, advanced solid tumor cells overexpressing Rspo3 in culture and in patient-derived xenograft models demonstrated inhibition of beta-catenin activity and suppression of tumor growth when treated with RSPO3 specific antibodies, suggesting RSPO3 may be a promising therapeutic target (PMID: 26719531).||26719531|