Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol LGR5
Synonyms FEX | GPR49 | GPR67 | GRP49 | HG38
Gene Description LGR5, leucine rich repeat containing G protein-coupled receptor 5, encodes a receptor that binds R-spondin and mediates Wnt signaling (PMID: 21909076, PMID: 21693646), plays a role in cytoneme formation (PMID: 25653388), and is a marker for intestinal stem cells (PMID: 17934449, PMID: 24677446) and cancer stem cells (PMID: 29416699, PMID: 28355176, PMID: 34857912). Increased LGR5 expression has been identified in colorectal cancer (PMID: 31814939) and epithelial ovarian cancer (PMID: 26113008).
Additional content available in CKB BOOST