Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | SOCS1 | ||||||||||
| Synonyms | AISIMD | CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP-3 | TIP3 | ||||||||||
| Gene Description | SOCS1, suppressor of cytokine signaling 1, is a member of a family of proteins which regulate cytokine production through a negative feedback loop involving inhibition of JAK kinase activity as well as interacting in a variety of other signaling networks (PMID: 21084693, PMID: 31984217) and also plays a role in protein degradation (PMID: 30761449). Mutations in SOCS1 are associated with a wide variety of cancers (PMID: 24757565) and dysregulated Socs1 expression has been identified in both heme and solid tumor types (PMID: 28228755). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
