Gene Detail

Gene Symbol TNFRSF10B
Synonyms CD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9
Gene Description TNFRSF10B, tumor necrosis factor receptor superfamily member 10B, is a cell surface receptor that binds TRAIL to activate the caspase cascade for induction of apoptosis (PMID: 25770212). Decreased expression of TNFRSF10B may reduced the effectiveness of anticancer drugs promoting apoptosis (PMID: 28624529, PMID: 28467689, PMID: 28798154).
Entrez Id 8795
Chromosome 8
Map Location 8p21.3
Canonical Transcript NM_003842


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