Gene Detail
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| Gene Symbol | TNFRSF10B | ||||||||||
| Synonyms | CD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9 | ||||||||||
| Gene Description | TNFRSF10B, TNF receptor superfamily member 10b, is a cell surface receptor that binds TRAIL to activate the caspase cascade for induction of apoptosis (PMID: 25770212). Decreased expression of TNFRSF10B may reduced the effectiveness of anticancer drugs promoting apoptosis (PMID: 28624529, PMID: 28467689, PMID: 28798154). | ||||||||||
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