Gene Detail


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Gene Symbol TRIM4
Synonyms RNF87
Gene Description TRIM4, tripartite motif containing 4, is a member of the RING family of E3 ubiquitin ligases, which plays a role in mitochondrial morphology, regulation of reactive oxygen species level, and oxidative stress-induced cell death (PMID: 26524401). Decreased Trim4 expression has been demonstrated in hepatocellular carcinoma (PMID: 32368282), and TRIM4 fusions have been identified in mucinous adenocarcinoma of the lung (PMID: 26200269) and Spitz tumors (PMID: 26013381).
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