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Gene Symbol CCNE1
Synonyms CCNE | pCCNE1
Gene Description CCNE1, cyclin E1, predominately interacts with CDK2 to regulate the cell-cycle in transition from G1 to S phase (PMID: 14965268, PMID: 27461360). Amplification and/or overexpression of CCNE1 is common in chemoresistant ovarian high grade serous carcinomas (PMID: 27461360, PMID: 32044108), and in general, is associated with poor prognosis in solid tumor types (PMID: 30026836).
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