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Gene Symbol MAP3K14
Synonyms FTDCR1B | HS | HSNIK | NIK
Gene Description MAP3K14, mitogen-activated protein kinase kinase kinase 14, encodes for a serine/threonine protein kinase that activates the NF-kappaB pathway, and plays a large role in immune regulation (PMID: 20685151, PMID: 22718757). MAP3K14 amplification has been identified in Hodgkin lymphoma, multiple myeloma, and splenic marginal zone lymphoma (PMID: 22469134).


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