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|Synonyms||BAM | BMH | CDLS3 | CSPG6 | HCAP | SMC3L1|
|Gene Description||SMC3, structural maintenance of chromosomes 3, is a component of the cohesin complex, which functions in cohesion of sister chromatids during mitosis (PMID: 24856830, PMID: 23776448, PMID: 29187575). SMC3 mutations have been identified in chronic myeloid neoplasms (PMID: 30138727) as well as several additional hematological and solid tumor types (PMID: 24335498, PMID: 24856830, PMID: 23955599).|
|Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|
|inact mut||unknown||loss of function||SMC3 inact mut indicates that this variant results in a loss of function of the Smc3 protein. However, the specific amino acid change has not been identified.|
|mutant||unknown||unknown||SMC3 mutant indicates an unspecified mutation in the SMC3 gene.|