Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | BOC | ||||||||||
| Synonyms | Boi | CDON2 | ||||||||||
| Gene Description | BOC, BOC cell adhesion associated, oncogene regulated, encodes a member of the immunoglobulin/fibronectin III repeat family of receptor-like proteins that binds to Sonic hedgehog and regulates downstream signaling (PMID: 16647304, PMID: 21664576), plays a role in myogenic differentiation (PMID: 11782431, PMID: 12634428), synaptic development, and axon guidance (PMID: 17086203, PMID: 22445340). Increased BOC expression has been identified in medulloblastoma (PMID: 25263791), and a fusion with PLAG1 has been observed in lipoblastoma (PMID: 30857637) and uterine mesenchymal tumors (PMID: 30489320). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
