Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol CRB3
Synonyms
Gene Description CRB3, crumbs cell polarity complex component 3, regulates and maintains epithelial polarity through tight junctions (PMID: 31087799, PMID: 30980524) and is involved in epithelial-mesenchymal transition (PMID: 25552927). Methylation and decreased expression of CRB3 have been assocaited with poor prognosis in clear cell renal cell carcinoma (PMID: 31147860), and altered Crb3 expression levels have been observed in different subtypes of breast cancer (PMID: 31087799).


Additional content available in CKB BOOST