Gene Detail


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Gene Symbol S1PR2
Synonyms AGR16 | DFNB68 | EDG-5 | EDG5 | Gpcr13 | H218 | LPB2 | S1P2
Gene Description S1PR2, sphingosine-1-phosphate receptor 2, mediates sphingolipid signaling through activation of G-protein coupled receptors, thus plays a role in diverse cellular functions including wound healing, immune response, metabolism, and carcinogenesis (PMID: 23879641). S1PR2 inactivating mutations have been associated with diffuse large B-cell lymphoma (PMID: 26989186, PMID: 27980305), S1PR2 mutations have been identified in follicular lymphoma (PMID: 27959929), and overexpression of S1pr2 has been identified in bladder cancer (PMID: 30712233).
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