Gene Detail

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Gene Symbol IKBKE
Synonyms IKK-E | IKK-i | IKKE | IKKI
Gene Description IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon, is an I-kappaB family member and a serine/threonine protein kinase that regulates activation of NF-kappaB signaling in response to inflammation and infection (PMID: 15102433, PMID: 26025939, PMID: 31733040). IKBKE is overexpressed in several tumor types, including breast, glioma, pancreatic (PMID: 31733040), and non-small cell lung cancer (PMID: 31406474), and is amplified in triple-negative breast cancer (PMID: 26025939, PMID: 25365225).


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