Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol GAB2
Synonyms
Gene Description GAB2, GRB2-associated binding protein 2, is an adaptor protein, which upon activation by cytokines, growth factors and antigens, amplifies the Shp2-Ras-Erk and PI3K-Akt signalling pathways (PMID: 26095858). Amplification and/or overexpression of Gab2 has been observed in breast cancer (PMID: 12140767), neuroblastoma (PMID: 28329685), melanoma (PMID: 19509136) and may play a role in BCR-ABL1 mediated leukemia (PMID: 28804122).


Additional content available in CKB BOOST