Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | CDC42 | ||||||||||
| Synonyms | CDC42Hs | G25K | TKS | ||||||||||
| Gene Description | CDC42, cell division cycle 42, is a member of the Ras GTPase superfamily that plays a key role in several cellular processes including cell polarization (PMID: 22560076, PMID: 2195038), actin cytoskeleton dynamics and filopodia formation (PMID: 9308960, PMID: 31330900, PMID: 9403696), cytokinesis (PMID: 8838660), motility, and invasion (PMID: 9403696). Cdc42 is overexpressed in various solid tumors including cervical cancer, pancreatic cancer, sarcoma (PMID: 29858187), non-small cell lung cancer (PMID: 19162367), melanoma (PMID: 17970806), breast cancer (PMID: 12237774), colorectal cancer (PMID: 18575765), and testicular cancer (PMID: 15269155). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
