Gene Detail


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Gene Symbol CDH1
Synonyms Arc-1 | BCDS1 | CD324 | CDHE | ECAD | LCAM | UVO
Gene Description CDH1, cadherin 1, type 1, encodes E-Cadherin and is a tumor suppressor (PMID: 30562755) involved in epithelial cell-cell adhesion, cell signaling, differentiation, and polarity (PMID: 18726070, PMID: 26674224). CDH1 germline mutations are associated with hereditary diffuse gastric cancer (PMID: 30562755) and somatic mutations are found in gastric, breast, colon, and NSCLC cancers (PMID: 27283171, PMID: 25184143).


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Variant Impact Protein Effect Variant Description Associated with drug Resistance
inact mut unknown loss of function CDH1 inact mut indicates that this variant results in a loss of function of the Cdh1 protein. However, the specific amino acid change has not been identified.
mutant unknown unknown CDH1 mutant indicates an unspecified mutation in the CDH1 gene.