Gene Detail
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| Gene Symbol | CDH1 | ||||||||||
| Synonyms | Arc-1 | BCDS1 | CD324 | CDHE | ECAD | LCAM | UVO | ||||||||||
| Gene Description | CDH1, cadherin 1, type 1, encodes E-Cadherin and is a tumor suppressor (PMID: 30562755) involved in epithelial cell-cell adhesion, cell signaling, differentiation, and polarity (PMID: 18726070, PMID: 26674224). CDH1 germline mutations are associated with hereditary diffuse gastric cancer (PMID: 30562755) and somatic mutations are found in gastric, breast, colon, and NSCLC cancers (PMID: 27283171, PMID: 25184143). | ||||||||||
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