Gene Detail

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Gene Symbol CDH1
Synonyms Arc-1 | BCDS1 | CD324 | CDHE | ECAD | LCAM | UVO
Gene Description CDH1, cadherin 1, type 1, encodes E-Cadherin and is a tumor suppressor (PMID: 30562755) involved in epithelial cell-cell adhesion, cell signaling, differentiation, and polarity (PMID: 18726070, PMID: 26674224). CDH1 germline mutations are associated with hereditary diffuse gastric cancer (PMID: 30562755) and somatic mutations are found in gastric, breast, colon, and NSCLC cancers (PMID: 27283171, PMID: 25184143).

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Molecular Profile Protein Effect Treatment Approaches
CDH1 A102T unknown
CDH1 A298T loss of function
CDH1 A299S unknown
CDH1 A403T unknown
CDH1 A592S unknown
CDH1 A592T unknown
CDH1 A634V gain of function
CDH1 A691T unknown
CDH1 A692T unknown
CDH1 A709V unknown
CDH1 A719V unknown
CDH1 A735V unknown
CDH1 A817V unknown
CDH1 A824Gfs*5 loss of function - predicted
CDH1 A824V unknown
CDH1 C163Afs*52 loss of function - predicted
CDH1 D221H unknown
CDH1 D254N unknown
CDH1 D254Y unknown
CDH1 D257G unknown
CDH1 D257N unknown
CDH1 D257V unknown
CDH1 D288N unknown
CDH1 D288V unknown
CDH1 D290G unknown
CDH1 D291Mfs*3 loss of function - predicted
CDH1 D291N unknown
CDH1 D313N unknown
CDH1 D370N unknown
CDH1 D400A unknown
CDH1 D400del unknown
CDH1 D400V unknown
CDH1 D402H unknown
CDH1 D402N unknown
CDH1 D402V unknown
CDH1 D418N unknown
CDH1 D433N unknown
CDH1 D549H unknown
CDH1 D549Y unknown
CDH1 D552N unknown
CDH1 D587H unknown
CDH1 D587Y unknown
CDH1 D644N unknown
CDH1 D764Gfs*5 loss of function - predicted
CDH1 D805* loss of function - predicted
CDH1 D858E unknown
CDH1 E165Q unknown
CDH1 E185V no effect
CDH1 E243* loss of function - predicted
CDH1 E243K unknown
CDH1 E243Q unknown
CDH1 E247* loss of function - predicted
CDH1 E247K unknown
CDH1 E261K unknown
CDH1 E273K unknown
CDH1 E336K unknown
CDH1 E35* loss of function - predicted
CDH1 E386K unknown
CDH1 E445A unknown
CDH1 E445Q unknown
CDH1 E463* loss of function - predicted
CDH1 E490K unknown
CDH1 E494* loss of function - predicted
CDH1 E497K unknown
CDH1 E512* loss of function - predicted
CDH1 E551K unknown
CDH1 E58* loss of function - predicted
CDH1 E58Q unknown
CDH1 E648* loss of function - predicted
CDH1 E757K loss of function
CDH1 E781D loss of function
CDH1 E806* loss of function - predicted
CDH1 E841K unknown
CDH1 E852Vfs*8 unknown
CDH1 F205S unknown
CDH1 F317S unknown
CDH1 F462Hfs*16 loss of function - predicted
CDH1 F499Lfs*38 loss of function - predicted
CDH1 F601L unknown
CDH1 F730Vfs*18 loss of function - predicted
CDH1 F98L unknown
CDH1 G169Rfs*5 loss of function - predicted
CDH1 G212E unknown
CDH1 G239R loss of function
CDH1 G239W unknown
CDH1 G278* loss of function - predicted
CDH1 G278R unknown
CDH1 G278V unknown
CDH1 G693D unknown
CDH1 G759Efs*11 loss of function - predicted
CDH1 H128Ifs*87 loss of function - predicted
CDH1 H92D unknown
CDH1 I192N unknown
CDH1 I248F unknown
CDH1 I505Sfs*17 loss of function - predicted
CDH1 I600T unknown
CDH1 inact mut loss of function
CDH1 K113E unknown
CDH1 K440N unknown
CDH1 K447* loss of function - predicted
CDH1 K557N unknown
CDH1 K668* loss of function - predicted
CDH1 K738R unknown
CDH1 L175P unknown
CDH1 L214P loss of function
CDH1 L214R unknown
CDH1 L249V unknown
CDH1 L452P unknown
CDH1 L583R loss of function
CDH1 L71F unknown
CDH1 L728* loss of function - predicted
CDH1 L731F unknown
CDH1 L731Ffs*39 loss of function - predicted
CDH1 L776M unknown
CDH1 L798V unknown
CDH1 L845V unknown
CDH1 loss loss of function
CDH1 M282I unknown
CDH1 M316V unknown
CDH1 M656* loss of function - predicted
CDH1 mutant unknown
CDH1 N256I unknown
CDH1 N294Kfs*6 loss of function - predicted
CDH1 N315S unknown
CDH1 N387H unknown
CDH1 N405S unknown
CDH1 N458I unknown
CDH1 N606I unknown
CDH1 N666S unknown
CDH1 N674K unknown
CDH1 N674Y unknown
CDH1 N867S unknown
CDH1 over exp no effect
CDH1 P125L unknown
CDH1 P159L unknown
CDH1 P159Lfs*56 loss of function - predicted
CDH1 P160Rfs*8 loss of function - predicted
CDH1 P201A unknown
CDH1 P201S unknown
CDH1 P260H unknown
CDH1 P277S unknown
CDH1 P30T unknown
CDH1 P373L loss of function
CDH1 P373R unknown
CDH1 P429L unknown
CDH1 P537L unknown
CDH1 P593S unknown
CDH1 P607S unknown
CDH1 P744S unknown
CDH1 P799R loss of function
CDH1 P825L unknown
CDH1 Q129* loss of function - predicted
CDH1 Q195* loss of function - predicted
CDH1 Q195K unknown
CDH1 Q23* loss of function - predicted
CDH1 Q255* loss of function - predicted
CDH1 Q307* loss of function - predicted
CDH1 Q346* loss of function - predicted
CDH1 Q351* loss of function - predicted
CDH1 Q383* loss of function - predicted
CDH1 Q448* loss of function - predicted
CDH1 Q503* loss of function - predicted
CDH1 Q511* loss of function - predicted
CDH1 Q610L unknown
CDH1 Q641* loss of function - predicted
CDH1 Q647* loss of function - predicted
CDH1 Q677* loss of function - predicted
CDH1 R222G unknown
CDH1 R222I unknown
CDH1 R224C unknown
CDH1 R224H unknown
CDH1 R335* loss of function - predicted
CDH1 R492I unknown
CDH1 R598* loss of function - predicted
CDH1 R63* loss of function - predicted
CDH1 R63* ERBB2 L869Q
CDH1 R63G unknown
CDH1 R65I unknown
CDH1 R732Q loss of function
CDH1 R74* loss of function - predicted
CDH1 R749W loss of function
CDH1 R868C unknown
CDH1 R90Q unknown
CDH1 R90W unknown
CDH1 S133F unknown
CDH1 S191N unknown
CDH1 S232C no effect - predicted
CDH1 S36Afs*20 loss of function - predicted
CDH1 S469Y unknown
CDH1 S559N unknown
CDH1 S70Pfs*13 loss of function - predicted
CDH1 S9* loss of function - predicted
CDH1 T118R loss of function
CDH1 T251K unknown
CDH1 T340A loss of function
CDH1 T340M unknown
CDH1 T366Rfs*5 loss of function - predicted
CDH1 T399_D400del unknown
CDH1 T522I unknown
CDH1 T560R loss of function
CDH1 V188D unknown
CDH1 V365I unknown
CDH1 V365Tfs*26 loss of function - predicted
CDH1 V454E unknown
CDH1 V460L unknown
CDH1 V475A unknown
CDH1 V660fs loss of function - predicted
CDH1 V694I unknown
CDH1 V737D unknown
CDH1 V832M loss of function
CDH1 W156* loss of function - predicted
CDH1 W156C unknown
CDH1 W4* loss of function - predicted
CDH1 W409* loss of function - predicted
CDH1 W409fs loss of function - predicted
CDH1 W409L unknown
CDH1 W409R loss of function
CDH1 W532* loss of function - predicted
CDH1 W638* loss of function - predicted
CDH1 wild-type no effect
CDH1 Y101C unknown
CDH1 Y190C unknown
CDH1 Y190H unknown
CDH1 Y302N unknown
CDH1 Y523* loss of function - predicted
CDH1 Y754Afs*5 loss of function - predicted
CDH1 Y835* unknown