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|Variant||FGFR2 - COL14A1|
|Gene Variant Descriptions||FGFR2-COL14A1 results from the fusion of FGFR2 and COL14A1 (PMID: 25485619). FGFR2-COL14A1 has been identified in lung cancer (PMID: 25485619), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, May 2020).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 - COL14A1 FGFR2 amp||colorectal adenocarcinoma||sensitive||PRN1371||Preclinical - Cell culture||Actionable||In a preclinical study, PRN1371 inhibited proliferation of colorectal adenocarcinoma cells harboring FGFR2 amplification and FGFR2-COL14A1 fusion in culture (PMID: 28978721).||28978721|
|FGFR2 - COL14A1 FGFR2 amp||colon cancer||sensitive||Derazantinib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of colon cancer cells harboring FGFR2 amplification and FGFR2-COL14A1 fusion in culture and in cell line xenograft models (PMID: 27627808).||27627808|