Gene Variant Detail

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Gene DNMT3A
Variant D876G
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions DNMT3A D876G lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). D876G disrupts Dnmt3a tetramer formation and leads to decreased Dnmt3a activity in in vitro assays (PMID: 22722925).
Associated Drug Resistance

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Transcript NM_022552
gDNA chr2:g.25234391T>C
cDNA c.2627A>G
Protein p.D876G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175629 chr2:g.25234391T>C c.2627A>G p.D876G RefSeq GRCh38/hg38
XM_017003526 chr2:g.25234391T>C c.2627A>G p.D876G RefSeq GRCh38/hg38
XM_005264175 chr2:g.25234391T>C c.2627A>G p.D876G RefSeq GRCh38/hg38
NM_022552 chr2:g.25234391T>C c.2627A>G p.D876G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
DNMT3A D876G loss of function