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Gene PALB2
Variant D584E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PALB2 D584E does not lie within any known functional domains of the Palb2 protein (UniProt.org). D584E has not been characterized in the scientific literature and therefore, its effect on Palb2 protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

PALB2 mutant PALB2 D584E

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Transcript NM_024675.4
gDNA chr16:g.23630402A>C
cDNA c.1752T>G
Protein p.D584E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407301.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_024675.3 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
XM_017023673.2 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_024675 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_001407297.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_001407300.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_001407299.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_001407298.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_001407302.1 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
XM_017023672.2 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
XM_017023673 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
XM_017023672 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38
NM_024675.4 chr16:g.23630402A>C c.1752T>G p.D584E RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References