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Gene STK11
Variant D176N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 D176N lies within the protein kinase domain of the Stk11 protein (UniProt.org). D176N results in failure to recruit Smarca2 (Brm) to DNA double strand breaks in cell culture (PMID: 23584481) and results in loss of kinase activity in an vitro assay (PMID: 9837816).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 D176N

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Transcript NM_000455.5
gDNA chr19:g.1220434G>A
cDNA c.526G>A
Protein p.D176N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618.3 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
XM_005259618 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
XM_005259617 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38
NM_000455 chr19:g.1220434G>A c.526G>A p.D176N RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References