Gene Variant Detail

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Gene STK11
Variant G61Afs*3
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 G61Afs*3 indicates a shift in the reading frame starting at amino acid 61 and terminating 3 residues downstream causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). G61Afs*3 has not been characterized however, due to the effects of other truncation mutations downstream of G61 (PMID: 23612973), G61Afs*3 is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance

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Transcript NM_000455
gDNA chr19:g.1207095delG
cDNA c.182delG
Protein p.G61Afs*3
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011528209 chr19:g.1219352_1219353insCCCCGTA c.181_182insCCCCGTA p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
NM_000455 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38
XM_005259618 chr19:g.1207095delG c.182delG p.G61Afs*3 RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
STK11 G61Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor