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Gene | TP53 |
Variant | P309S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 P309S lies within the CCAR2, HIPK1, and CARM1-interacting regions and the bipartite nuclear localization signal region of the Tp53 protein (UniProt.org). P309S results in constitutive activation of p21 in conjunction with P273H (PMID: 16061257), but has not been individually characterized and therefore, its effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon9 TP53 P309S |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673603G>A |
cDNA | c.925C>T |
Protein | p.P309S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126113.3 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7673603G>A | c.925C>T | p.P309S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R273H TP53 P309S | colorectal cancer | sensitive | NSC59984 | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with NSC59984 induced Tp53 pathway signaling, degradation of mutant Tp53, and cell death in a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215). | 26294215 |
TP53 R273H TP53 P309S | colorectal cancer | sensitive | Cisplatin + NSC59984 | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of Platinol (cisplatin) and NSC59984 worked synergistically to decrease viability of a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215). | 26294215 |