Gene Variant Detail

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Gene TP53
Variant P309S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 P309S lies within the CCAR2, HIPK1, and CARM1-interacting regions and the bipartite nuclear localization signal region of the Tp53 protein (UniProt.org). P309S results in constitutive activation of p21 in conjunction with P273H (PMID: 16061257), but has not been individually characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 P309S

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Transcript NM_000546.6
gDNA chr17:g.7673603G>A
cDNA c.925C>T
Protein p.P309S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_000546 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673603G>A c.925C>T p.P309S RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R273H TP53 P309S colorectal cancer sensitive NSC59984 Preclinical - Cell culture Actionable In a preclinical study, treatment with NSC59984 induced Tp53 pathway signaling, degradation of mutant Tp53, and cell death in a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215). 26294215
TP53 R273H TP53 P309S colorectal cancer sensitive Cisplatin + NSC59984 Preclinical - Cell culture Actionable In a preclinical study, the combination of Platinol (cisplatin) and NSC59984 worked synergistically to decrease viability of a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215). 26294215