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|Protein Effect||gain of function - predicted|
|Gene Variant Descriptions||ABL1 D276G lies within the protein kinase domain of the Abl1 protein (UniProt.org). D276G has been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL and results in increased kinase activity (PMID: 15510211), and therefore, is predicted to lead to a gain of Abl1 protein function.|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ABL1 mutant ABL1 act mut ABL1 D276G
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ABL1 D276G||gain of function - predicted|