Gene Variant Detail

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Gene ROS1
Variant L567V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 L567V lies within fibronectin type-III domain 3 of the Ros1 protein (UniProt.org). L567V has been identified in sequencing studies (PMID: 27284491), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, May 2022).
Associated Drug Resistance

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Transcript NM_002944.2
gDNA chr6:g.117389410G>C
cDNA c.1699C>G
Protein p.L567V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_017011172 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_017011173 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
NM_002944 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_011536051 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117389410G>C c.1699C>G p.L567V RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
ROS1 L567V unknown