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Gene AXL
Variant G736W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions AXL G736W lies within the protein kinase domain of the Axl protein (UniProt.org). G736W has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
Associated Drug Resistance
Category Variants Paths

AXL mutant AXL inact mut AXL G736W

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Transcript NM_021913.5
gDNA chr19:g.41257502G>T
cDNA c.2206G>T
Protein p.G736W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_021913.5 chr19:g.41257502G>T c.2206G>T p.G736W RefSeq GRCh38/hg38
NM_021913.4 chr19:g.41257502G>T c.2206G>T p.G736W RefSeq GRCh38/hg38
NM_021913 chr19:g.41257502G>T c.2206G>T p.G736W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References