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Gene AXL
Variant G736W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions AXL G736W lies within the protein kinase domain of the Axl protein (UniProt.org). G736W has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
Associated Drug Resistance

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Transcript NM_021913.4
gDNA chr19:g.41257502G>T
cDNA c.2206G>T
Protein p.G736W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_021913 chr19:g.41257502G>T c.2206G>T p.G736W RefSeq GRCh38/hg38
NM_021913.4 chr19:g.41257502G>T c.2206G>T p.G736W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
AXL G736W loss of function - predicted